Intravenous amiodarone treatment may cause hepatic toxicity. N‑acetylcysteine (NAC) is a powerful
antioxidant, reduces the level of free radicals by increasing glutathione levels, and is used in
acetaminophen intoxication. An 83‑year‑old female Caucasian patient who had congestive heart
failure and implantable cardioverter‑defibrillator was admitted to the hospital with palpitations and
confusion. After analysis of ICD device, ventricular tachycardia, ventricular fibrillation runs of patient
and intervention of ICD device with electric shocks were noticed. Intravenous 1200 mg amiodarone
infusion was administered as treatment. Later, her transaminase levels increased dramatically. Hepatic
injury due to intravenous administration of amiodarone was diagnosed and 1200 mg/day intravenous
NAC was given. After 72 h of NAC treatment, hepatic enzymes were found to be recovering. After
parenteral amiodarone administration, patients must be monitored for acute hepatotoxicity. This
article accentuates the benefits of NAC treatment in drug‑induced liver injury.