The present study aims to assess the impact of a blast on a five-story reinforced concrete (RC) frame structure through computational analysis. The study examines the effect of different standoff distances, which is the distance between the source of the explosion and the structure, on the structural behavior. The standoff distances being studied are 5, 10, and 15 meters, and a charge weight of 25 kilograms is used in each scenario. Blast loads can cause severe damage to the exterior frames of a building, resulting in the collapse of walls and internal structural elements. Older buildings not designed for blast loads are particularly vulnerable and can be completely destroyed or damaged in the event of an explosion. Direct impact, structural collapse, fire, debris, and smoke from an explosion can threaten the occupants, leading to injury or death. The study’s results help identify the best practices for designing structures to withstand the impact of an explosion and protect occupants from harm. The results will provide valuable information for architects, engineers, and building designers, as well as for disaster response and preparedness organizations. The study will contribute to understanding the structural response to blast loads and the influence of the blast on the structure.