Berberine’s therapeutic prospects in parkinson’s disease : a spotlight on cholesterol regulation for cognitive improvement
Publication details: Bangalore Association of Pharmaceutical Teachers of India (APTI) 2024Edition: Vol.58(4), Oct-DecDescription: 1102-1109pSubject(s): Online resources: In: Indian journal of pharmaceutical education and researchSummary: Cholesterol synthesized in astrocytes of the cerebrum plays a pivotal role in regulating hippocampal neurogenesis and cognitive function. Dysregulation of cholesterol metabolism has emerged as a key contributor to the pathogenesis of Parkinson’s disease. Elevated cholesterol levels in the brain are associated with increased oxidative stress and subsequent neurodegeneration of hippocampal pyramidal neurons, culminating in cognitive impairment. Berberine, an isoquinoline alkaloid has the potential to modulate cholesterol synthesis through HMG-CoA inhibition. This study aims to elucidate the therapeutic potential of berberine in mitigating cognitive impairment in Parkinson’s disease by conferring protection to hippocampal pyramidal neurons through regulating cholesterol homeostasis.| Item type | Current library | Status | Barcode | |
|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2025-0287 |
Cholesterol synthesized in astrocytes of the cerebrum plays a pivotal role in regulating hippocampal neurogenesis and cognitive function. Dysregulation of cholesterol metabolism has emerged as a key contributor to the pathogenesis of Parkinson’s disease. Elevated cholesterol levels in the brain are associated with increased oxidative stress and subsequent neurodegeneration of hippocampal pyramidal neurons, culminating in cognitive impairment. Berberine, an isoquinoline alkaloid has the potential to modulate cholesterol synthesis through HMG-CoA inhibition.
This study aims to elucidate the therapeutic potential of berberine in mitigating cognitive impairment in Parkinson’s disease by conferring protection to hippocampal pyramidal neurons through regulating cholesterol homeostasis.
There are no comments on this title.
Click on an image to view it in the image viewer