Development and characterization of liquisolid compact to improve dissolution of an antihypertensive drug
Publication details: Banagalore Association of Pharmaceutical Teachers of India (APTI) 2024Edition: Vol.58(4), Oct-DecDescription: 1198-1204pSubject(s): Online resources: In: Indian journal of pharmaceutical education and researchSummary: The goal of the current research was to use the straight forward, scalable, and economical Liquisolid compact to improve the dissolution profile of the poorly soluble medication Ramipril. Objectives: Utilising various polymers and liquid vehicles, the study’s objective was to develop and characterise Liquisolid compact. Materials and Methods: Ramipril liquisolid were formulated using Propylene glycol and PEG 400 as liquid vehicle, MCC as a carrier, Aerosil 200 as a coating material. By using differential scanning calorimetry, the crystallinity of the newly developed drug formulation and the interactions between excipients were investigated. No interaction between the medication and excipients was established by FTIR tests.| Item type | Current library | Status | Barcode | |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2025-0297 |
The goal of the current research was to use the straight forward, scalable, and economical Liquisolid compact to improve the dissolution profile of the poorly soluble medication Ramipril.
Objectives:
Utilising various polymers and liquid vehicles, the study’s objective was to develop and characterise Liquisolid compact.
Materials and Methods:
Ramipril liquisolid were formulated using Propylene glycol and PEG 400 as liquid vehicle, MCC as a carrier, Aerosil 200 as a coating material. By using differential scanning calorimetry, the crystallinity of the newly developed drug formulation and the interactions between excipients were investigated. No interaction between the medication and excipients was established by FTIR tests.
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