Background: According to Ayurvedic literature, Ghrita is highly recommended for the management of psychiatric
problems since it acts on the brain and has a lipophilic activity, making it well-known that it can pass the bloodbrain
barrier. In traditional Ayurvedic medicine, Brahmi Ghrita, a polyherbal formulation is recommended
for management of various psychological disorders such as Alakshmi (Inauspicious) Unmada (Insanity), and
Apasmara (Epilepsy). Drug quality is a basic necessity in this day and age, and analytical testing can help combat
impurities or subpar pharmaceuticals. Methodology: Physicochemical analysis, including moisture content, acid
value, saponification value, iodine value, and refractive index, was conducted in accordance with Ayurvedic
pharmacopeia and the World Health Organization guidelines. Results: Studyproduces analytical data for
Brahmi Ghrita. Conclusion: By employing a wide array of testing procedures, manufacturers are able to ensure
compliance with regulatory requirements and supply consumers with a better product that effectively delivers
Brahmi’s therapeutic benefits. In conclusion, analytical tool can be applied to quality control, contaminant
detection, chemical identification, research and development, of Ghrita kalpana.