Papaya is English word papita.The biological source of papaya is Carica papaya Linn and it belonging to family Caricaceae. It is originated from Mesoamerican Centre, Central America and Southern Mexico and its cultivated in the tropical and subtropical region of Brazil, Australia, Malaysia, Chinlta, India, Thailand etc. The different parts of the Carica papaya plant including leaves, seeds, latex and fruit exhibited to have medicinal value. There is a lot of latex in the papaya fruit, leaf, and stem. Papain and chymopapain are two of the enzymes found in the latex of unripe papaya fruit. It is used in antioxidant anti diabetic, anti hypertensive, Anti fertility, anti fungal, anthelmintic, anti inflammatory, anti bacterial, anti-cancer, anti HIV, Anti sickling. This review focus on different pharmacological properties of papaya. Papaya has neutraceutical fruit due to its medicinal properties. Minerals, vitamins, carotenoids, flavonoids, alkaloids, monoterpenoids, and lycopene are all present in the entire plant.Moreover, papaya fruit is utilized to make a wide variety of dishes, including pickles, jam, jelly, and canned slices. Fruit peels used in cosmetics. Papaya Leaf, bark, stem and roots also shown by the insecticide activity.Ripe fruit can be safe, but unripe Fruit contain Papain and they can damage the esophagus. The fruit has a large oval shape, yellowish green skin, and yellow flesh. The various traditional medical systems, including Ayurveda, are well aware of the therapeutic benefits of papaya fruit and other parts.