Nanosponge can be considered as an effective carrier among all the novel drug delivery systems
based on nanotechnology. It is a newer class of nanoparticulate system having 3-dimensional scaffold
structure and nanometric cavity size. Owing to the highly porous nature, nanosponge can offer several
benefits like capability to entrap multiple active moieties, loading both hydrophobic and hydrophilic
drugs, enhancing the drug solubility followed by promoting the bioavailability of drug molecules, and
exhibiting programmable release. These spherical shaped colloidal nanocarriers have the potential to
elevate the solubility for poorly soluble drugs through their inclusion and non-inclusion activities. The
drugs belonging to Biopharmaceutical Classification System class II and IV are the suitable candidates
to be developed as nanosponge formulation for increasing their solubility. Emulsion solvent diffusion
method, ultrasound-assisted synthesis, high pressure homogenization etc. are the popular methods for
preparation of nanosponge. An extensive variety of additives such as polymers, copolymers, cross-linkers,
surfactants are used for releasing the drugs to the target site in a predictable manner through various
routes of administration like oral, parenteral, topical. In this review, an overview of nanosponge and its
recent advancement in field of drug delivery system along with future perspectives will be discussed.