In vitro anti angiogenetic activity of traditional plants saraca asoca, glycyrrhizia glabra and curcuma longa beneficial for endometriosis treatment
Publication details: Mumbai Indian Pharmacutical Association 2024Edition: Vol.86(2), Mar-AprDescription: 78-85pSubject(s): Online resources: In: Indian journal of pharmaceutical sciencesSummary: The development of angiogenesis plays an essential role in the growth and survival of endometriosis. The aim was to determine the in vitro anti-angiogenic effect of Saraca asoca, Glycyrrhiza glabra, and Curcuma longa ethanolic extract in chick embryos by emphasizing its total phenolic and flavonoid contents in the sample. It was determined by Folin-Ciocalteu and aluminum chloride methods respectively. Anti-angiogenesis assay was done in chorioallantoic membrane. The high amount of total phenol and flavonoid was obtained from all three plant extracts and may be responsible for the bioactivity of the crude extract. Saraca asoca exhibits high phenolic content and anti-angiogenic activity followed by Curcuma longa with rich flavonoid and Glycyrrhiza glabra showed moderate activity for all the assays. A significant anti-angiogenic effect was observed for Saraca asoca (73.65+0.021) % and Curcuma longa (67.65+0.024) % than reference drug dienogest (62.42+0.02) % in the study. Search for new therapeutic agents with anti-angiogenic potential rich in plant secondary metabolites like phenols and flavonoids are need of the hour. The results successfully reveal that the above- mentioned plants used in traditional medicines could be used for treating angiogenesis-related diseases like endometriosis.| Item type | Current library | Status | Barcode | |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2025-1002 |
The development of angiogenesis plays an essential role in the growth and survival of endometriosis. The aim
was to determine the in vitro anti-angiogenic effect of Saraca asoca, Glycyrrhiza glabra, and Curcuma longa
ethanolic extract in chick embryos by emphasizing its total phenolic and flavonoid contents in the sample.
It was determined by Folin-Ciocalteu and aluminum chloride methods respectively. Anti-angiogenesis assay
was done in chorioallantoic membrane. The high amount of total phenol and flavonoid was obtained from all
three plant extracts and may be responsible for the bioactivity of the crude extract. Saraca asoca exhibits high
phenolic content and anti-angiogenic activity followed by Curcuma longa with rich flavonoid and Glycyrrhiza
glabra showed moderate activity for all the assays. A significant anti-angiogenic effect was observed for Saraca
asoca (73.65+0.021) % and Curcuma longa (67.65+0.024) % than reference drug dienogest (62.42+0.02)
% in the study. Search for new therapeutic agents with anti-angiogenic potential rich in plant secondary
metabolites like phenols and flavonoids are need of the hour. The results successfully reveal that the above-
mentioned plants used in traditional medicines could be used for treating angiogenesis-related diseases like
endometriosis.
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