Gamma activity model for treatment-resistant bipolar psychotic mania
Publication details: Mumbai Wolter Kluwer 2015Edition: Vol.47(2), Mar-AprDescription: 215-218pSubject(s): Online resources: In: Indian Journal of PharmacologySummary: The objective was to investigate the effect of clozapine on spontaneous gamma activity in treatment-resistant bipolar psychotic mania. Methods: Patients with treatment-resistant (TR) bipolar psychotic mania on clozapine monotherapy and nontreatment-resistant bipolar psychotic mania patients receiving lithium were prospectively studied for 6 weeks on severity of psychopathology and 30–49 Hz gamma spectral power. Results: Spectral power significantly increased in the lithium group and decreased in the clozapine group; no within group significant difference found. Conclusions: We propose a model highlighting the role of gamma spectral power and modulations of GABAergic neurotransmission in TR bipolar psychotic mania.| Item type | Current library | Status | Barcode | |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2025-1777 |
The objective was to investigate the effect of clozapine on spontaneous gamma activity in treatment-resistant bipolar psychotic mania.
Methods:
Patients with treatment-resistant (TR) bipolar psychotic mania on clozapine monotherapy and nontreatment-resistant bipolar psychotic mania patients receiving lithium were prospectively studied for 6 weeks on severity of psychopathology and 30–49 Hz gamma spectral power.
Results:
Spectral power significantly increased in the lithium group and decreased in the clozapine group; no within group significant difference found.
Conclusions:
We propose a model highlighting the role of gamma spectral power and modulations of GABAergic neurotransmission in TR bipolar psychotic mania.
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