Agiba, Ahmed M. <br/><br/>
INSIGHTS INTO FORMULATION TECHNOLOGIES AND NOVEL ST RATEGIES FOR THE DESIGN  OF ORALLY DISINTEGRATING DOSAGE FORMS: A COMPREHENS IVE INDUSTRIAL REVIEW  

 - Vol.11(9) 
 - M P  Innovare Academic Sciences Pvt Ltd  2019 
 - 8-20p. 
<br/><br/> Among the various routes of administration, the ora<br/>l route remains the most convenient and commonly em<br/>ployed route for drug delivery. The oral <br/>conventional drug delivery systems have some drawba<br/>cks, such as possibility of gastrointestinal destru<br/>ction of labile molecules, low absorption of <br/>macromolecules, slow onset of action, and unavoidab<br/>le fluctuation in the concentration of drugs which <br/>can either lead to under-or over medication with <br/>concomitant adverse effects, especially for drugs w<br/>ith small therapeutic index. Therefore, it became e<br/>ssential to design novel oral drug delivery systems<br/>to  achieve  quick  dissolution,  absorption,  rapid  ons<br/>et  of  action  and  reduction  of  drug  dose.  Among  thos<br/>e  novel  drug  delivery  systems  are  oral <br/>disintegrating tablets (ODTs). The purpose of this <br/>review article is to report the recent advances in <br/>ODT systems with emphasis on their preparations, <br/>characterizations and applications. Also, it highli<br/>ghts future prospects and possible challenges in th<br/>e development of an ideal ODT system.  
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS