TY  - GEN
AU  - Abdul Raheem T.
AU  - Singh, Ranjeet
TI  - FORMULATION AND COMPARATIVE EVALUATION OF ONDANSETR ON HYDROCHLORIDE  MOUTH DISSOLVING TABLETS IN INDIA 
PY  - 2019///
CY  - M P
PB  - Innovare Academic Sciences Pvt Ltd
KW  - PHARMACEUTICS
N2  - Objective: 
The  aim  of  the  present  study  was  to  prepare  the  ond
ansetron  hydrochloride  Mouth  Dissolving  Tablets  (MD
Ts)  followed  by  its 
comparison with ethical and non-ethical (generic) m
arketed tablets. 
Methods: 
Prior  to  the  formulation,  drug  excipient  compatibil
ity  study  was  carried  out  by  FTIR  spectroscopy.  The
  λ
max 
was  determined  by  UV 
spectroscopy.  The  ondansetron  hydrochloride  MDTs  we
re  prepared  by  direct  compression  method  using  Sodi
um  Starch  Glycolate  (SSG)  as  super 
disintegrant  and  camphor  as  a  sublimating  agent.  Th
en  the  prepared  MDTs  were  subjected  to  evaluation  o
f  post  compression  parameters  such  as 
thickness  and  diameter,  weight  variation,  wetting  t
ime,  hardness,  friability,  disintegration  and  disso
lution.  The  results  obtained  were  compared 
with that of ethical and non-ethical marketed ondan
setron hydrochloride 4 mg tablets. 
Results: 
The  λ
max 
was  found  at  310  nm.  FTIR
study  revealed  that  excipients  used  in  the  prepared
  formulations  are  compatible  with  the  drug.  The 
thickness and diameter was in the range of 2.646 to
 3.27 mm and 6.0 to 8.12 mm, respectively. Friabili
ty was in the range of 0.43 to 0.88 % and had 
a  slightly  higher  friability (1.27%)  for  sublimated
  tablets. Wetting time  and  disintegration  time  were
  in the range of  15  to  40  sec  and  23 to  50  sec, 
respectively.  The  100  %  drug  release  was  found  with
in  180  sec  for  all  the  codes.  These  results  were  th
en  compared  with  non-ethical  film  coated 
ondansetron marketed tablets. 
Conclusion: 
Ondansetron  hydrochloride  MDT  4  mg  tablets  prepared
  in  the  laboratory  were  under  specified  IP  limits. 
The  experimental  findings 
demonstrated  that  any  of  these  ethical  and  non-ethi
cal  tablets  of  ondansetron  hydrochloride  can  be  sel
ected,  advised  by  the  physician  or 
pharmacist, as per the patient’s need and economica
l status.
UR  - https://innovareacademics.in/journals/index.php/ijpps/article/view/33840/20641
ER  -