TY  - GEN
AU  - Chanda, Shilpee
AU  - Juvekar, Archana R.
TI  - IN VITRO  ANTI -INFLAMMATORY ACTIVITY OF SYRINGIC ACID
PY  - 2019///
CY  - M P
PB  - Innovare Academic Sciences Pvt Ltd
KW  - PHARMACEUTICS
N2  - Objective: 
The present study was carried out to investigate
 the
in vitro
 anti
-inflammatory
 activity of syringic acid (SA).
Method
s: 
SA  was  tested  for 
it's 
in 
vitro
  anti
-inflammatory  activity
  at  different  concentrations
  in  protein  denaturation,  proteinase  inhibition
  and
human red blood cell (HRBC) 
membrane stabilization assay. The reference drugs used were aspirin and diclofenac sodium.
Result
s: 
SA 
showed 
concentration
-dependent   inhibition   of   protein   denaturation   and   proteinase   activity   with   a
   half
-maximal 
inhibitory 
concentration (
IC
50
) value of 49.38
±0.56
 μg
/ml
 and 53.73
±0.27
 μg
/ml
 respectively. Heat-
induced 
haemolysis
 was inhibited by SA with
 an IC
50 
value 
of 
57.13
±0.   24
 μg
/ml
. SA 
also 
inhibit
ed
 the hypotonicity
-induced 
haemolysis
 (IC
50 
Conclusio
n: 
From  the  present  study,  we  can  conclude  that  SA  possesses  appreciable  anti
-inflammatory 
effect  against  denaturation  of  proteins,  
proteinase  activity
,  and
  human  red  blood  membrane  stabilization  assays.  Further  studies  are  required  for  determining  the  possible  mechanisms  
behind its anti
-inflammatory action
UR  - https://innovareacademics.in/journals/index.php/ijpps/article/view/30387/19157
ER  -