TY  - GEN
AU  - Yadav, A. V.
AU  - Upasani, C. D.
TI  - NEPHROPROTECTIVE ACTIVITY OF PLUMERIA RUBRA AGAINST  CISPLATIN INDUCED NEPH ROTOXICITY IN EXPERIMENTAL RATS 
PY  - 2019///
CY  - M P
PB  - Innovare Academic Sciences Pvt Ltd
KW  - PHARMACEUTICS
N2  - Objective:
  The  current  study  was  designed  to  evaluate  the  pro
tective  effect  of  standardized  hydroalcoholic  extra
ct  of  Plumeria  rubra  (HAEPR) 
against cisplatin-induced nephrotoxicity in Wistar 
rats.  
Methods:
 HAEPR was administered orally at 3 dose levels (100
,200,400 mg/kg). Vitamin E (250 mg/kg) was used as 
a Standard nephroprotective 
agent.  The  kidney  function  test  (estimation  of  seru
m  creatinine,  albumin,  blood  urea  nitrogen)  oxidati
ve  stress  study (estimation  of  superoxide 
dismutase, malondialdehyde activity) and histologic
al examination of kidneys was conducted. 
Results:
 The efficacy of HAEPR was compared with Cisplatin (
CP) treated group. Serum creatinine and BUN was sig
nificantly (p<0.01) elevated in 
CP-treated group compared to the control group. HAE
PR (100,200 mg/kg) and Vitamin E (250 mg/kg) signif
icantly (p<0.01) decreased the serum 
creatinine  and  BUN  levels.  CP  treated  group  exhibit
ed  significant  (p<0.01)  decrease  in  albumin  when  co
mpared  to  control.  Significant  (p<0.01) 
increase in the serum albumin level was found in HAE
PR (100,200 mg/kg) and Vitamin E (250 mg/kg) compar
ed to CP group. Significant (p<0.01) 
decrease in the activity of SOD was observed in the
 CP group as compared to control. HAEPR (100 and 20
0 mg/kg) and Vitamin E (250 mg/kg) 
significantly  (p<0.01)  increased  SOD  levels.  HAEPR  (
400  mg/kg)  significantly  (p<0.05)  increased  SOD  lev
els.  HAEPR  (100,200,400  mg/kg) 
significantly (p<0.01) decreased MDA levels as comp
ared to CP group. Histopathological examination of t
he kidneys showed that HAEPR markedly 
ameliorated Cisplatin-induced renal tubular necrosi
s. An extract was found effective at all doses, alt
hough low dose (100 mg/kg) was found to be 
more effective and comparable with the standard gro
up (Vitamin E 250 mg/kg).
UR  - https://innovareacademics.in/journals/index.php/ijpps/article/view/31561/19678
ER  -