Mapunda, Pensia E. <br/><br/>
EVALUATION OF FREE RADICAL SCAVENGING ABILITY AND ANTIRADICAL ACTIVITIES OF  XIMENIA CAFFRA  FRUIT EXTRACTS  AT DIFFERENT RIPENING STAGES 

 - Vol.11(1) 
 - M P  Innovare Academic Sciences Pvt Ltd  2019 
 - 55-60p. 
<br/><br/> Objective: <br/>To<br/> evaluate<br/> the<br/> free radical scavenging<br/> ability<br/> and <br/>antiradical activities<br/> of <br/>Ximenia <br/>caffra<br/>fruit <br/>extracts <br/>in their different ripening stages.<br/>Method<br/>s: <br/>Using  standard  procedures<br/>, <br/>Ximenia<br/>  caffra<br/>fruit  extracts  were  determined<br/>  for  ferrous  ion<br/>s  chelating  ability,  nitric  oxide  and <br/>hydroxyl <br/>radical  scavenging  ability<br/>.  Antiradical <br/>activities  were <br/>assessed  using  1<br/>,1-diphenyl<br/>-2-picrylhydrazyl  (DPPH<br/>)  in  which<br/>  the  fruit  extracts  were  <br/>evaluated  for  the  <br/>number  of  antiradical  units  (AU<br/>515<br/>),  the  number  of  antiradical  units  per  1  mg  of  extracts  (EAU<br/>515<br/>)  and  the  t<br/>otal  number  of  <br/>antiradical <br/>unit<br/>s per 1g of raw fruits<br/> (TAU<br/>515<br/>Result<br/>s: <br/>The fruit extracts exhibited significant<br/> higher <br/>ferrous ion chelating and free radical <br/>scavenging <br/>capacity <br/>compared to<br/> synthetic <br/>antioxidant<br/>s <br/>(standard<br/>).  Fruit  extracts  <br/>in  early  <br/>ripening  stage<br/>  (ERS)<br/>  exhibit<br/>ed<br/>  strong<br/>er<br/>  ion  chelation<br/>,  nitric  oxide  <br/>and <br/>hydroxyl<br/>  radical<br/>  scavenging  ability  with <br/>low <br/>effective  fruit  extract  concentration  require<br/>d  to  reduce  free  radicals  by  50<br/>%<br/>  (EC<br/>). <br/>50<br/>)  that  were<br/>  14,  25  and  30<br/>μg<br/>/ml<br/>  respectively <br/>than <br/>the <br/>late<br/>ripening <br/>stage<br/>  (LRS)<br/>  extracts<br/>.  The fruit<br/> extracts  also  showed <br/>high<br/>  AU<br/>515<br/>,  EAU<br/>515<br/>  and<br/>  TAU<br/>515<br/>.  The  values<br/>  of <br/>AU<br/>515<br/>  ranged  from  0.93  to  0.95,<br/>  while<br/>EAU<br/>515<br/> from <br/>78.30 to<br/> 79.34<br/> and TAU<br/>515 <br/>Conclusio<br/>n: <br/>Based on these observations<br/>Ximenia<br/> caffra<br/>is potentially <br/>beneficial<br/> to human health due to its<br/> strong <br/>ability to scavenge<br/> free radicals<br/>. <br/>Its <br/>utilization <br/>can potentially<br/> reduce the risk of degen<br/>erative<br/> diseases<br/> to human<br/> beings. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS