ESTIMATION OF PHARMACOKINETIC PARAMETERS AND ACCURACY OF THE PREDICTED EQUATION FOR LITHIUM DOSE IN CHILDRE N: A PILOT STUDY AT THE YUWAPRASART WAITHAYOPATHUM CHILD PSYCHIATRIC HOSPITAL
- Vol.11(1)
- M P Innovare Academic Sciences Pvt Ltd 2019
- 72-78p.
Objective : The purpose of the study was to estimate the pharmacokinetic parameters and calculate the prec ision (%RMSE) of the predicted l ithium concentration equation. Method s : This research was studied from blood Lithium levels of Children who had visited Yuwaprasa rt Waithayopathum Child Psychia tric Hospital from 31 December 2009 -1 January 2011 The accuracy and precision of the equation were evaluated by the mathematical principle. The assist package software (WIN -NONLIN) was used to create pharmacokinetic parameters. Result s : Twenty -nine patien ts were recruited. The characteristics (mean +SD) presented as the followin g; age = 15.79 +2.6 4 y , weight = 69.75+22.28 kg and the daily dose = 858.62+ 274.53 mg. The trough Lithium concentrations (mean +SD) = 0.56+ 19 mg/l . The kinetic parameter (Mean +SD) pres ented as the followin g; t 1/2 Conclusio n : In conclusion, the modified Yukawa equation may be used for the prediction of l ithium concentration with 6.39% RMSE. =7.23 +3.38 hr., ke =0.12 +0.07 hr -1, Vd = 48.83 +15.60 L, AUC0 -12 =11.01 +5.61 mg x hr /l. The population pharmacokinetic parameter s; ke, and AUC (0 - ∞) = 0.151 hr -1 and 169.81, mg x hr./l respectively. The mod ified equation from Yukawa for l ithium cleara nce calculation and prediction l ithium concentrations were CL (mL/min) = [36.5+(0.242x BW (kg) -7.79]/Scr (mg/dL) and l ithium concentration (mg /l) = 4 x Dose (mg) /CL (mL/min)x73.89, respectively with 6.39 %RMSE (test for 20 patients data).