TY  - GEN
AU  - Dholakia, Mansi
AU  - Dave, Richa
TI  - NEWER OPHTHALMIC IN SITU GEL OF MOXIFLOXACIN HYDROC HLORIDE: OPTIMIZATION  USING BOX BEHNKEN STATISTICAL DESIGN 
PY  - 2018///
CY  - M P
PB  - Innovare Academic Sciences Pvt Ltd
KW  - PHARMACEUTICS
N2  - Objective: 
The  present  research  work  aims  at  describing  the  fo
rmulation  and  evaluation  of  the  ocular  delivery  sys
tem  of  moxifloxacin 
hydrochloride (MH) based on the concept of ion sens
itive in situ gelations. 
Methods: 
In situ gel was prepared by a hot method using 0.6%
 of gelrite, 0.25% hydroxypropylmethylcellulose (HP
MC K
4
M) and 0.023% tamarind 
gum as bioadhesive polymers for sustained drug rele
ase. Optimization was done by Box Behnken Design wi
th different concentration of gelrite (X
1
), 
HPMC K
4
M (X
2
) and tamarind gum (X
3
) as independent variables. In situ gel was optimiz
ed based on mucoadhesion index (Y1), Gel strength (
Y2) 
and 
in vitro
 drug release (Y3). Influence of the quantitative v
ariable on the dependent variable was predicted by 
a polynomial equation.  
Results: 
Infrared spectroscopy excluded any interaction betw
een drug and excipients. The selected independent v
ariables significantly influenced 
the responses and were able to sustain the drug rel
ease. The prepared gel with a pH of 6.8 to 7.4 exhi
bited non-newtonian flow with no ocular 
irritation. The formulation remained stable with no
 change in pH and viscosity after 30 d of stability 
study.  
Conclusion: 
Thus, moxifloxacin hydrochloride (MH) in situ gel i
s a viable alternative to a conventional delivery s
ystem with the properties of 
sustained drug release, prolonged ocular retention,
 and improved corneal penetration.
UR  - https://innovareacademics.in/journals/index.php/ijpps/article/view/26979/16278
ER  -