Manimekalai, P. <br/><br/>
https://innovareacademics.in/journals/index.php/ijpps/article/view/32537/21243 

 - Vol.11(12) 
 - M P  Innovare Academic Sciences Pvt Ltd  2019 
 - 40-45p. 
<br/><br/> Objective<br/>:<br/>The  objective  of  the  present  study  is  to  evaluate  the  effect  of  Phthalate  analogues  of  diclofenac  in  Freund’s  complete  adjuva<br/>nt  (FCA)  <br/>induced Arthritis in the <br/>rat.<br/>Method<br/>s: <br/>Twenty four female albino wistar rats were enrolled in this study and are divided into 4 groups (six each). The groups were designed as <br/>follow<br/>s: <br/>Group <br/>I: vehicle control, Group I<br/>I:    arthritic control, Group II<br/>I: diclofenac treated, Group I<br/>V: <br/>phthalate analogue of diclofenac treated. Various <br/>assessments  such  as  anti<br/>-arthritic  activity,  biochemical  estimations,  haematological  parameters,  ulcerogenesis,  radiological  and  histopathological  <br/>studies were evaluated.<br/>Result<br/>s: <br/>Arthritic control group exhibited significant <br/>increase in the level of paw volume,<br/> arthritic score (p<<br/>0.0001), Serum glutamic pyruvic transaminase <br/>(SGPT) (p<0.001), Serum glutamic oxaloacetic transaminase (SGOT) p<0.01), rheumatoid arthritis factor, C-<br/>reactive protein (CRP), White Blood Cells (WBC), <br/>Creatinine <br/>and<br/>  uric  acid  and  a  significant  decrease  in  Red  Blood  Cells  (RBC).  Increased  swelling  of  joints,  bony  destruction  and  profound  ulceration  were  <br/>observed in <br/>the <br/>Arthritic control group. All these conditions were reversed in diclofenac and phthalate analogue of diclofenac groups.<br/>Conclusio<br/>n: <br/>We  conclude  that  phthalate  analogue  of  diclofenac  shows  potent  anti-<br/>arthritic<br/>  activity  with  milder  ulceration  when  compared  to  <br/>diclofenac treatment.  
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS