TY  - GEN
AU  - Sharma, Dheeraj Kumar
AU  - Singh, Neeraj Kumar
TI  - Role of Testosterone in Swimming Exercise-induced Analgesia in Rats
PY  - 2019///
CY  - Karnataka
PB  - Association of Pharmaceutical Teachers of India (APTI)
KW  - PHARMACEUTICS
N2  - Objective:  “Feel  good  effect”  of  exercise  is  well  known.  Activation  of  pain  inhibitory  mechanisms  after  exercise  is  also  well  documented.  Swimming  is  considered  as  a  beneficial exercise as well as health-promoting sport. The significance of testosterone in swimming exercise-induced analgesia is yet to be understood. Therefore, it is worthwhile to investigate the significance of testosterone in swimming exercise-induced analgesia. Materials and Methods: The basal tail flick latencies of all animals were recorded by using tail flick analgesiometer. In order to observe the effect of testosterone on swimming exercise-induced  analgesia,  testicles  of  animals  of  some  groups  were  surgically removed.  Then  animals  were  subjected  to  swimming  sessions  of  different  patterns. After swimming, tail flick latencies were measured. Results: Swimming sessions resulted in increase in pain thresholds of all animals. Castration negatively affected the degree of  analgesia  achieved  in  rats.  However,  daily  treatment  of  testosterone  propionate (500μg/kg,  s.c.)  improved  swim-induced  analgesia  in  castrated  rats.  Moreover,  daily administration of naloxone hydrochloride (1mg/kg, i.p.) fifteen min prior to swimming suppressed testosterone therapy resulted in an increase in swim-induced analgesia in castrated animals. Conclusion: We concluded that testosterone plays a significant role in swimming exercise-induced analgesia in male Wistar albino rats and this positive effect of testosterone on pain threshold might be mediated through its probable effect on the endogenous opioid system
UR  - https://www.ijper.org/sites/default/files/IndJPhaEdRes_53_4_675.pdf
ER  -