TY  - GEN
AU  -  Khajuria, Kanika
AU  - Gupta, Seema
TI  - Comparison of pregabalin and nortriptyline on sleep, quality of life in postherpetic neuralgia: a prospective, randomised, open-label, parallel study
PY  - 2021///
CY  - M P
PB  - Innovare Academic Sciences Pvt Ltd
KW  - PHARMACEUTICS
N2  - Objective:Aim of the present study was to compare the effectsof pregabalinand nortriptyline onsleep and qualityof life in patients of postherpetic neuralgia (PHN).Methods: The present study was conducted in48patients of PHN attending the outpatient department (OPD)of Dermatology, Government Medical College Jammu.  Based  oninclusion/exclusion  criteria  patients  were  randomized  into two  treatment  groups.One  group  received  pregabalin  150 mg/day  and the other  group  was  treated  with nortriptyline25  mg/day.  The  patientswere  followed  upto eightweeks  and  assessed for  Sleep (Medical Outcomes Study sleep scale)and quality of life (Euro QOL-5D-5L score). Clinicians Global Impression of Change (CGIC)scoreand Patient Global Impression of Change(PGIC)score were used toevaluate overall clinical improvement.Results:Both drugs significantly improved all parametersstudied (p<0.0001).On comparison,both drugs had similar effectson sleep and quality of life.However, pregabalinwas found to be better than nortriptyline at eight weeksonCGIC (p<0.004) and PGIC (p<0.0003)scores.Conclusion:Both pregabalin and nortriptyline wereequallyeffectivein improving sleep and quality of life.Overall clinical improvement was better with pregabalin than nortriptyline at eight weeks
UR  - https://innovareacademics.in/journals/index.php/ijpps/article/view/41244/24891
ER  -