TY  - GEN
AU  - Almoshari, Yosif 
AU  - Mohammad Intakhab Alam
TI  - Formulation, characterization, and evaluation of doxorubicin-loaded cubosome as a cytotoxic potentiator against HCT-116 colorectal cancer cells
PY  - 2022///
CY  - Karnataka
PB  - Association of Pharmaceutical Teachers of India (APTI)
KW  - PHARMACEUTICS
N2  - Background: Colorectal cancer (CRC) has grown to be the world’s fourth-biggest cause
of cancer-related mortality. It is critical to identify more effective treatment options for
it. Objectives: Doxorubicin a potent antineoplastic agent is widely used but has severe
adverse effects. Therefore, our objective is to use cubosome as an efficient drug delivery
system to reduce the off-target effects and increase the cytotoxic effects in CRC cells.
Materials and Methods: Pluronic F127-Based Cubosomes were prepared by low energy
stirring method and loaded with doxorubicin. Physicochemical characteristics were
studied using X-ray diffraction, dynamic light scattering, microscopic techniques, FTIR
UV spectrophotometer, and entrapment efficiency.
In vitro activity of doxorubicin-loaded
cubosomes was studied on HCT-116 cells. Results: The prepared cubosomes have the
required nano-size and the FTIR results showed the presence of both doxorubicin and
Pluronic F-127. The entrapment efficiency of doxorubicin was high too. DOX-CBs have
a better cytotoxic effect and induced ROS and reduced NO levels in HCT-116 cells.
Conclusion: The obtained results show that doxorubicin-loaded cubosomes can be used
to increase the cytotoxic effect in CRC cells and can be used with other chemotherapeutic
agents
UR  - https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-723.pdf
ER  -