TY  - GEN
AU  -  Zhang, Yi-Heng
AU  - Fang, Ze-Yu 
TI  - Synthesis of transition metal complexes of isoniazid derivatives and urease inhibition activity detection
PY  - 2022///
CY  - Karnataka
PB  - Association of Pharmaceutical Teachers of India (APTI)
KW  - PHARMACEUTICS
N2  - It have been reported that the transition metal complex of Schiff base ligands have the
ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes
[Cd2
(L)2·(H 2
O)] (1), [Pb(L)·, [Pbe2
) were synthesized based on chelating hydrazone
ligand
N‘-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds were tested
by single crystal X-ray diffraction and determined by structure and tested for urease
resistance
in vitro. The complex 2 exhibited better the activities of inhibiting than the
positive control acetohydroxamic acid with an IC50 =2.5
μM, while the complex 1
showed weak activity, and complex 2 acted as an effective urease inhibitor
UR  - https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-573.pdf
ER  -