TY  - GEN
AU  - Bhardwaj, Kanika
AU  - Rajawat, Neelu Kanwar
TI  - Development of Alpha-Synuclein protein model against therapeutic aspects of Parkinson’s disease
PY  - 2024///
CY  - Mumbai
PB  - Wolter Kluwer
KW  - PHARMACOLOGY
N2  - Parkinson’s disease (PD) is the most common neurodegenerative disease caused by the steady depletion of dopamine in the striatum due to the loss of dopaminergic neurons. Most of the current therapeutics work on rebuilding the striatal dopamine level through oral administration of levodopa which stops the symptoms of PD. But there is a long-term motor complication with these dopamine precursors. Moreover, no preventive treatment is available for PD. Thus, before finding a therapeutic treatment for PD, it is necessary to first understand the basic cause of PD. Moreover, alpha-synuclein oligomerization can be the major factor in PD. From the UniProt database, protein information was extracted, and the model was designed by homology modeling technique and validated by the model validation server. Hence, the designed model has 96.5% most favored region and 0% disallowed region. Therefore, the model is stable based on RC plot parameters
UR  - https://journals.lww.com/iphr/fulltext/2024/01000/development_of_alpha_synuclein_protein_model.7.aspx
ER  -