TY  - GEN
AU  - Kumar, Vikas
AU  - Vardhan, Gyan
TI  - Novel ultra-performance liquid chromatography detection method development and validation for paclitaxel and its major metabolite in human plasma  Kumar, Vikas; Vardhan, Gyan; Sehrawat, Amit1; Handu, Shailendra2; Dhamija, Puneet2
PY  - 2024///
CY  - Mumbai
PB  - Wolter Kluwer
KW  - PHARMACOLOGY
N2  - Paclitaxel is a promising anticancer drug for patients with ovarian, breast, lung, gastrointestinal, genitourinary, prostate, and head-and-neck cancers. Paclitaxel follows nonlinear pharmacokinetics. The major metabolite of paclitaxel is 6-alpha-hydroxy paclitaxel, mediated by CYP2C8, while metabolism to two of its minor metabolites, 3’-p-hydroxypaclitaxel and 6a, 3’- p-dihydroxypaclitaxel, is catalyzed by CYP3A4. Therapeutic drug monitoring of paclitaxel could be a promising approach to improve the efficacy and safety of paclitaxel correct personalized doses and improve the overall benefit–risk ratio. A novel and highly sensitive chromatographic method for the detection of paclitaxel and its metabolite has been proposed that allows quantification in human plasma with 100% accuracy in terms of recovery without significant intraday or interday variations
UR  - https://journals.lww.com/iphr/fulltext/2024/07000/a_novel_ultra_performance_liquid_chromatography.4.aspx
ER  -