Kumar, Shashi Ranjan <br/><br/>
Gamma activity model for treatment-resistant bipolar psychotic mania 

 - Vol.47(2), Mar-Apr 
 - Mumbai  Wolter Kluwer  2015 
 - 215-218p. 
<br/><br/> The objective was to investigate the effect of clozapine on spontaneous gamma activity in treatment-resistant bipolar psychotic mania.<br/>Methods: <br/><br/>Patients with treatment-resistant (TR) bipolar psychotic mania on clozapine monotherapy and nontreatment-resistant bipolar psychotic mania patients receiving lithium were prospectively studied for 6 weeks on severity of psychopathology and 30–49 Hz gamma spectral power.<br/>Results: <br/><br/>Spectral power significantly increased in the lithium group and decreased in the clozapine group; no within group significant difference found.<br/>Conclusions: <br/><br/>We propose a model highlighting the role of gamma spectral power and modulations of GABAergic neurotransmission in TR bipolar psychotic mania. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACOLOGY