TY  - GEN
AU  - Kumar, Shashi Ranjan
AU  - Sinha, Vinod Kumar
TI  - Gamma activity model for treatment-resistant bipolar psychotic mania
PY  - 2015///
CY  - Mumbai
PB  - Wolter Kluwer
KW  - PHARMACOLOGY
N2  - The objective was to investigate the effect of clozapine on spontaneous gamma activity in treatment-resistant bipolar psychotic mania.
Methods: 

Patients with treatment-resistant (TR) bipolar psychotic mania on clozapine monotherapy and nontreatment-resistant bipolar psychotic mania patients receiving lithium were prospectively studied for 6 weeks on severity of psychopathology and 30–49 Hz gamma spectral power.
Results: 

Spectral power significantly increased in the lithium group and decreased in the clozapine group; no within group significant difference found.
Conclusions: 

We propose a model highlighting the role of gamma spectral power and modulations of GABAergic neurotransmission in TR bipolar psychotic mania
UR  - https://journals.lww.com/iphr/fulltext/2015/47020/gamma_activity_model_for_treatment_resistant.18.aspx
ER  -