TY  - GEN
AU  - Raut, R.
AU  - Patil, A.
AU  - Munipalli, V. K.
TI  - Reverse phase high performance liquid chromatographic method for determination of regorafenib in tablet dosage form
PY  - 2018///
CY  - Mumbai
PB  - Indian Drug Manufacture's Association - IDMA
KW  - PHARMACEUTICS
KW  - PHLC
KW  - Regorafenib
KW  - Method development
KW  - Validation
N2  - A simple precise and rapid Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method has been developed for quantitative determination of Regorafenib in tablet dosage form. In this method Hypersil Gold (C18, 150mm× 4.6mm id, 3μ) column with mobile phase consisting of Trifluoroacetic acid (0.2% v/v) and Acetonitrile in the ratio of (50: 50 v/v) at 400C in an isocratic mode was used. The detection was carried out at 260 nm and 20μL injection volume was selected with the flow rate 1mL/min. The linearity range of Regorafenib shows concentration between 5-200 μg/mL. The regression coefficient obtained was 0.999. Retention time of Regorafenib was found to be 6.49 minutes. Acetonitrile and Water in the ratio of (3:1) was used as a diluent. The method was validated as per ICH guidelines and is simple, fast, accurate, precise and can be applied for routine quality control analysis of Regorafenib in tablet dosage form
ER  -