Yahya, Shaymaa, M. <br/><br/>
Preliminary investigation of HTR1A gene Expression levels in autism spectrum disorders 

 - Vol. 11(8) 
 - Bhopal  Innovare Academic Sciences Pvt Ltd  2019 
 - 1-3 
<br/><br/> This study was conducted to explore the expression levels of HTR1A gene in a sample of Egyptian autistic children.<br/><br/>Methods: Thirty autistic patients (18 boys, 12 girls) and 20 controls were enrolled in the study. From each child, we isolated RNA samples from whole blood. Quantitative Real-Time PCR (qRT-PCR) was used to measure the gene expressions of HTR1A and normalized to the house keeping gene, beta-actin.<br/><br/>Results: The HTR1A gene expression of healthy controls and ASD subjects were varied significantly (p =0.0062). As compared to control healthy subjects, the HTR1A expressions were greatly reduced in samples of ASD.<br/><br/>Conclusion: HTR1A gene expression level is a candidate gene for further studies to explore its potential roles in ASD related pathways. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS