Preliminary investigation of HTR1A gene Expression levels in autism spectrum disorders
Publication details: Bhopal Innovare Academic Sciences Pvt Ltd 2019Edition: Vol. 11(8)Description: 1-3Subject(s): Online resources: In: International journal of pharmacy and pharmaceutical scienceSummary: This study was conducted to explore the expression levels of HTR1A gene in a sample of Egyptian autistic children. Methods: Thirty autistic patients (18 boys, 12 girls) and 20 controls were enrolled in the study. From each child, we isolated RNA samples from whole blood. Quantitative Real-Time PCR (qRT-PCR) was used to measure the gene expressions of HTR1A and normalized to the house keeping gene, beta-actin. Results: The HTR1A gene expression of healthy controls and ASD subjects were varied significantly (p =0.0062). As compared to control healthy subjects, the HTR1A expressions were greatly reduced in samples of ASD. Conclusion: HTR1A gene expression level is a candidate gene for further studies to explore its potential roles in ASD related pathways.| Item type | Current library | Status | Barcode | |
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School of Pharmacy Archieval Section | Not for loan | 2019983 |
This study was conducted to explore the expression levels of HTR1A gene in a sample of Egyptian autistic children.
Methods: Thirty autistic patients (18 boys, 12 girls) and 20 controls were enrolled in the study. From each child, we isolated RNA samples from whole blood. Quantitative Real-Time PCR (qRT-PCR) was used to measure the gene expressions of HTR1A and normalized to the house keeping gene, beta-actin.
Results: The HTR1A gene expression of healthy controls and ASD subjects were varied significantly (p =0.0062). As compared to control healthy subjects, the HTR1A expressions were greatly reduced in samples of ASD.
Conclusion: HTR1A gene expression level is a candidate gene for further studies to explore its potential roles in ASD related pathways.
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