Gene amplification requires a biological sample whi
ch is collected prior to the demands. The sample fo
r such analysis plays a vital role as they serve
as a resource for the core material-Deoxyribonuclei
c acid. A sample for gene amplification or any anal
ysis would be collected prior to the demands
and type of analysis. Human blood has been an essent
ial resource of DNA from the commencement of DNA ex
traction in the 19th century. After then
several protocols developed according to the requir
ement of both samples of different forms and their
retrieval as various forms and methods. The
sample has various characteristics and prerequisite
s when collected for gene analysis. Some important
characteristics of sample collection methods
are significant, which are not widely taken. This w
ork analyses various general sample collection prot
ocols and highlights some of the major
characteristics and prerequisites for the sample. T
his work initiates and delivers to attain the core
of genomics by bringing out the basic raw
materials importance and consequences on amplificat
ion which is highly sensitive.