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EVALUATION OF FREE RADICAL SCAVENGING ABILITY AND ANTIRADICAL ACTIVITIES OF XIMENIA CAFFRA FRUIT EXTRACTS AT DIFFERENT RIPENING STAGES

By: Contributor(s): Publication details: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(1)Description: 55-60pSubject(s): Online resources: In: International journal of pharmacy and pharmaceutical scienceSummary: Objective: To evaluate the free radical scavenging ability and antiradical activities of Ximenia caffra fruit extracts in their different ripening stages. Method s: Using standard procedures , Ximenia caffra fruit extracts were determined for ferrous ion s chelating ability, nitric oxide and hydroxyl radical scavenging ability . Antiradical activities were assessed using 1 ,1-diphenyl -2-picrylhydrazyl (DPPH ) in which the fruit extracts were evaluated for the number of antiradical units (AU 515 ), the number of antiradical units per 1 mg of extracts (EAU 515 ) and the t otal number of antiradical unit s per 1g of raw fruits (TAU 515 Result s: The fruit extracts exhibited significant higher ferrous ion chelating and free radical scavenging capacity compared to synthetic antioxidant s (standard ). Fruit extracts in early ripening stage (ERS) exhibit ed strong er ion chelation , nitric oxide and hydroxyl radical scavenging ability with low effective fruit extract concentration require d to reduce free radicals by 50 % (EC ). 50 ) that were 14, 25 and 30 μg /ml respectively than the late ripening stage (LRS) extracts . The fruit extracts also showed high AU 515 , EAU 515 and TAU 515 . The values of AU 515 ranged from 0.93 to 0.95, while EAU 515 from 78.30 to 79.34 and TAU 515 Conclusio n: Based on these observations Ximenia caffra is potentially beneficial to human health due to its strong ability to scavenge free radicals . Its utilization can potentially reduce the risk of degen erative diseases to human beings.
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Objective:
To
evaluate
the
free radical scavenging
ability
and
antiradical activities
of
Ximenia
caffra
fruit
extracts
in their different ripening stages.
Method
s:
Using standard procedures
,
Ximenia
caffra
fruit extracts were determined
for ferrous ion
s chelating ability, nitric oxide and
hydroxyl
radical scavenging ability
. Antiradical
activities were
assessed using 1
,1-diphenyl
-2-picrylhydrazyl (DPPH
) in which
the fruit extracts were
evaluated for the
number of antiradical units (AU
515
), the number of antiradical units per 1 mg of extracts (EAU
515
) and the t
otal number of
antiradical
unit
s per 1g of raw fruits
(TAU
515
Result
s:
The fruit extracts exhibited significant
higher
ferrous ion chelating and free radical
scavenging
capacity
compared to
synthetic
antioxidant
s
(standard
). Fruit extracts
in early
ripening stage
(ERS)
exhibit
ed
strong
er
ion chelation
, nitric oxide
and
hydroxyl
radical
scavenging ability with
low
effective fruit extract concentration require
d to reduce free radicals by 50
%
(EC
).
50
) that were
14, 25 and 30
μg
/ml
respectively
than
the
late
ripening
stage
(LRS)
extracts
. The fruit
extracts also showed
high
AU
515
, EAU
515
and
TAU
515
. The values
of
AU
515
ranged from 0.93 to 0.95,
while
EAU
515
from
78.30 to
79.34
and TAU
515
Conclusio
n:
Based on these observations
Ximenia
caffra
is potentially
beneficial
to human health due to its
strong
ability to scavenge
free radicals
.
Its
utilization
can potentially
reduce the risk of degen
erative
diseases
to human
beings.

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