Objective:
Method
s:
SLNs consist of a solid lipid matrix
where the drug
was
incorporated
. Surfactants of GRAS grade were used t
o avoid aggregation and to
stabilize the SLNs.
DST
-SLN
s formulations of varying con
centrations were prepared by high
-speed
homogenization technique and evaluated for
drug excipients compatibility study, poly
-dispersity index, particle size analysis, surface
morphology, zeta potential
, and
drug release features.
The aim of present work wa
s to formulate and
evaluate
Dasatinib
(DST)
loaded solid lipid nanoparticles
(SLNs)
as a potential antic
ancer
drug delivery system
by enhancing its solubility.
Result
s:
It was observed that
DST
-SLNs with optimum
quantities o
f poloxome
r: lecithin ratio showed 88.06% drug release
in 6h
with good
entrapment efficiency of 76.9±0.84 %
. Particle size, Polydispersity
index, zeta potential and drug entrapment efficiency for the optimized
formula
tion was found to be
optimum
. Stability studies
revealed that the entrapment efficiency of the SLN dispersion stored in 4
°C was stable.
Conclusio
n
:
Thus, it can be concluded that
the
formulations
of
DST loaded SLNs
are suitable carriers for improving the
solubility and dissolution
related problems.