Objective
:
The objective of the present study is to evaluate the effect of Phthalate analogues of diclofenac in Freund’s complete adjuva
nt (FCA)
induced Arthritis in the
rat.
Method
s:
Twenty four female albino wistar rats were enrolled in this study and are divided into 4 groups (six each). The groups were designed as
follow
s:
Group
I: vehicle control, Group I
I: arthritic control, Group II
I: diclofenac treated, Group I
V:
phthalate analogue of diclofenac treated. Various
assessments such as anti
-arthritic activity, biochemical estimations, haematological parameters, ulcerogenesis, radiological and histopathological
studies were evaluated.
Result
s:
Arthritic control group exhibited significant
increase in the level of paw volume,
arthritic score (p<
0.0001), Serum glutamic pyruvic transaminase
(SGPT) (p<0.001), Serum glutamic oxaloacetic transaminase (SGOT) p<0.01), rheumatoid arthritis factor, C-
reactive protein (CRP), White Blood Cells (WBC),
Creatinine
and
uric acid and a significant decrease in Red Blood Cells (RBC). Increased swelling of joints, bony destruction and profound ulceration were
observed in
the
Arthritic control group. All these conditions were reversed in diclofenac and phthalate analogue of diclofenac groups.
Conclusio
n:
We conclude that phthalate analogue of diclofenac shows potent anti-
arthritic
activity with milder ulceration when compared to
diclofenac treatment.