EFFECT OF BLUMEA LACERA ON TISSUE GSH, LIPID PEROX IDATION AND HEPATIC CELLS IN ETHANOL INDUCED HEPATOTOXICITY IN RATS
Publication details: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(12)Description: 46-50pSubject(s): Online resources: In: International journal of pharmacy and pharmaceutical scienceSummary: Objective: To evaluate hepatoprotecti ve effects of ethanol extract of aerial part of Blumea lacera (BLEE) against ethanol - induced hepatotoxicity in rats. Method s: The in vivo antioxidant activity of BLEE was assessed by determining the tissue g lutathione (GSH) and lipid peroxidation (LPO) lev els. The BLEE at the doses of 200 and 400 mg/kg and silymarin 100 mg /kg administered to the ethanol challenged rats. The effect s of BLEE and silymarin on Physical and Biochemical Parameters were measured. Similarly , histopathological changes of the liver w ere studied. Result s : The BLEE showed in vivo antioxidant activity. A significant (P<0.001) decrease in SGOT, SGPT, ALP, total and direct bilirubin was observed in BLEE treated group at doses i.e. 200 mg/kg and 400 mg/kg as compared to intoxicated group. Liver damage in animal pretreated with BLEE was minimal with distinct preservation of structures and the architectural frame of the hepatic cells.| Item type | Current library | Status | Barcode | |
|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020970 |
Objective:
To evaluate hepatoprotecti
ve effects of ethanol extract of aerial part of
Blumea lacera
(BLEE) against ethanol
-
induced hepatotoxicity in rats.
Method
s:
The
in vivo
antioxidant activity of BLEE was assessed by determining the tissue g
lutathione (GSH) and lipid peroxidation
(LPO) lev
els. The
BLEE at the doses of 200 and 400
mg/kg and silymarin 100 mg
/kg
administered to the ethanol challenged rats. The effect
s of BLEE and silymarin on
Physical and Biochemical Parameters were measured. Similarly
, histopathological changes of
the liver w
ere studied.
Result
s
:
The BLEE
showed
in vivo
antioxidant activity.
A significant (P<0.001) decrease
in SGOT, SGPT, ALP, total and direct bilirubin
was observed
in BLEE
treated group at doses i.e.
200 mg/kg and 400 mg/kg as compared to intoxicated group.
Liver
damage in animal pretreated with BLEE was
minimal with distinct preservation of structures and the
architectural frame of the hepatic cells.
There are no comments on this title.
Click on an image to view it in the image viewer