Background: In the presented study; the Effects of Arbutin (ARB) on the Rat Erythrocyte
and serum fatty acid profile which is exposed to potassium bromate (KBrO3
) were
investigated. Materials and Methods: In this study, 32 Wistar albino rats weighing
250-300 g were used divided into 4 groups. Groups 1: control, group 2: KBrO3 (single
dose 100 mg / kg gavage), group 3: ARB (50 mg / kg / day (ip) for 5 days), group 4:
KBrO3 + ARB. At the end of the 5th day, alteration of fatty acid profile in erythrocyte
and serum of rats in all groups was examined. Results: Rat serum essential fatty acid;
palmitic acid (C16:0), myristic acid (C14:0), stearic acid (C18:0), oleic acid (C18:1),
linoleic acid (C18:2), erythrocyte major fatty acids; palmitic acid (C16:0), myristic acid
(C14:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), arachidic acid
(C20:0), eicosenoic acid (C20:1), and lignoceric acid (C24:0). In addition, in our studied
serum and erythrocytes; Total monounsaturated fatty acids (MUFA) varied between
8.91 ± 0.53- 11.71 ± 2.55 and 33.71 ± 2.12- 37.11 ± 2.12, respectively. It was
determined that total polyunsaturated fatty acids (PUFA) varied between 5.90 ± 1.29-
9.96 ± 1.18 and 14.72 ± 3.66- 22.13 ± 4.82, respectively. Conclusion: In our study,
alterations in fatty acid contents were observed, and results suggesting that arbutine
affects the enzymes involved in Fatty acid metabolism and has an effect on fatty acid
amounts.