In this review we have elaborated about number of hypothesis postulated to understand
the mechanism of hydrotropic agents, although majority of the postulated hypothesis
haven’t justified the solubility enhancement mechanism. Further to it the articles focuses
upon the parameters affecting enhancement of solubilizing ability. Hydrotropes are
extensively used in drug solubilization, extraction agents for various phytoconstituents,
separation agent used for pharmaceutical analysis, as well as for increasing the rate and
yield of a chemical reaction due to their unique features. Because of this, hydrotropic
solutions possess high industrial demand. While mixed hydrotropy is mostly used in
enhancement of solubility, extraction of phytoconstituents and separation by the use
of more than one hydrotropic agent. This review article also highlights the applications
and future prospects with the employment of hydrotropes and hydrotropic agents in
novel drug delivery or parental or oral or tropical systems to enhance solubility profile the
drugsare also discussed.