Synthesis of transition metal complexes of isoniazid derivatives and urease inhibition activity detection
Publication details: Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(2), Apr-JuneDescription: 573-579pSubject(s): Online resources: In: Indian journal of pharmaceutical education and researchSummary: It have been reported that the transition metal complex of Schiff base ligands have the ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes [Cd2 (L)2·(H 2 O)] (1), [Pb(L)·, [Pbe2 ) were synthesized based on chelating hydrazone ligand N‘-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds were tested by single crystal X-ray diffraction and determined by structure and tested for urease resistance in vitro. The complex 2 exhibited better the activities of inhibiting than the positive control acetohydroxamic acid with an IC50 =2.5 μM, while the complex 1 showed weak activity, and complex 2 acted as an effective urease inhibitor.| Item type | Current library | Status | Barcode | |
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School of Pharmacy Archieval Section | Not for loan | 2022-1450 |
It have been reported that the transition metal complex of Schiff base ligands have the
ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes
[Cd2
(L)2·(H 2
O)] (1), [Pb(L)·, [Pbe2
) were synthesized based on chelating hydrazone
ligand
N‘-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds were tested
by single crystal X-ray diffraction and determined by structure and tested for urease
resistance
in vitro. The complex 2 exhibited better the activities of inhibiting than the
positive control acetohydroxamic acid with an IC50 =2.5
μM, while the complex 1
showed weak activity, and complex 2 acted as an effective urease inhibitor.
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