One pot synthesis of 4,5-dibromo-3,6-diarylpyridazine from 1,4-diarylbuta-1,3-diyne
Publication details: New Delhi CSIR 2022Edition: Vol.61, NovDescription: 1159-1163pSubject(s): Online resources: In: Indian journal of chemistry (Section B)Summary: Pyridazines are an important scaffold present in various pharmacophores due to their significant physiochemical features of drug molecules. Laboratory synthesis of pyridazines is highly important because their natural sources are very rare. A one-pot two-step methodology has been developed for the synthesis of 4,5-dibromo-3,6-diarylpyridazines starting from easily available starting material 1,4-diarylbuta-1,3-diynes. The reaction goes through the electrophilic addition of Br+ ion with alkyne bonds followed by nucleophilic addition of hydrazine and then intramolecular cyclization.| Item type | Current library | Status | Barcode | |
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School of Pharmacy Archieval Section | Not for loan | 2023-0635 |
Pyridazines are an important scaffold present in various pharmacophores due to their significant physiochemical features of drug molecules. Laboratory synthesis of pyridazines is highly important because their natural sources are very rare. A one-pot two-step methodology has been developed for the synthesis of 4,5-dibromo-3,6-diarylpyridazines starting from easily available starting material 1,4-diarylbuta-1,3-diynes. The reaction goes through the electrophilic addition of Br+ ion with alkyne bonds followed by nucleophilic addition of hydrazine and then intramolecular cyclization.
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