UV spectrophotometric method development and validation for the determination of nirmatrelvir antiviral drug in bulk and its in-house formulation
Publication details: Raipur Asian Pharma Press 2024Edition: Vol.14(3), Jul-SepDescription: 127-130pSubject(s): Online resources: In: Asian journal of pharmaceutical analysisSummary: UV spectrophotometry was performed by Lab India Analytical UV 3092 using methanol as medium. The resolution process was performed in the range of 200–400nm to determine the maximum absorption (? max). The ?max of Nirmatrelvir was found to be 210nm. Measure the absorbance of 10, 20, 30, 40, 50, and 60µg/ml drug solution and measure the maximum absorbance at 210 nm with a blank control. Then draw a graph from the concentration on the X-axis and the absorbance on the Y-axis to get a straight line. Validation parameters such as linearity, precision, specificity, LOD and LOQ, accuracy and robustness were evaluated according to ICH guidelines.| Item type | Current library | Status | Barcode | |
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School of Pharmacy Archieval Section | Not for loan | 2025-0016 |
UV spectrophotometry was performed by Lab India Analytical UV 3092 using methanol as medium. The resolution process was performed in the range of 200–400nm to determine the maximum absorption (? max). The ?max of Nirmatrelvir was found to be 210nm. Measure the absorbance of 10, 20, 30, 40, 50, and 60µg/ml drug solution and measure the maximum absorbance at 210 nm with a blank control. Then draw a graph from the concentration on the X-axis and the absorbance on the Y-axis to get a straight line. Validation parameters such as linearity, precision, specificity, LOD and LOQ, accuracy and robustness were evaluated according to ICH guidelines.
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