Objective:
To an assessment of potential drug
-drug interactions in hypertensive patients in a tertiary care hospital.
Method
s:
A prospective, observational study was
conducted at a tertiary care hospital
, Erode for
a period of 8 mo
. A sample of 480
patients was
asse
ssed for P
DDIs using
drug checker in
Micromedex
®
Result
s:
A total of
430
patients were analyzed and it was found to be 396 (82.50%) hypertensive patients had PDDIs
, and a sum total of 1160 PDDIs
were observed.
Pot ential drug
-drug interactions (PDDIs) higher in female
hypertensive patients
[255
(64.39%)
] compared to males. Incidences of
PDDIs were found to be higher in the age group of 60
-70 y
were
[177
(44.69%
)] and incidences of interactions based on the duration of (4
-6 d
)
hospital stays
were 272
(68.68%
).
Moreover,
49.24%
of patients were found to be prescribed with more than 7 drugs, with higher incidences of
PDDIs. Some of the most common drug interacting
pair was between aspirin and clopidogrel combination observed in
325 PDDIs in
the
major, with
pharmacodynamics
in nature.
-2.7
.
Conclusio
n
:
Clinical
pharmacist
ought to
have the role of regular
monitoring
of drug therapy
in
identifying
and preventing the medications that have
the potential to cause drug
-drug interactions
, thereby minimizing the undesirable outcomes in drug medical care
and
improving
the quality
of care