| 000 | a | ||
|---|---|---|---|
| 999 |
_c11231 _d11231 |
||
| 003 | OSt | ||
| 005 | 20200213150249.0 | ||
| 008 | 200213b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
||
| 100 |
_912219 _aAntony, Benny |
||
| 245 | _aACUTE AND SUB CHRONIC TOXICITY STUDIES OF PURIFIED WITHANIA SOMNIFERA EXTRACT IN RATS | ||
| 250 | _aVol.10(12) | ||
| 260 |
_aM P _bInnovare Academic Sciences Pvt Ltd _c2018 |
||
| 300 | _a41-46p. | ||
| 520 | _aObjective: The objective of the present study was to evaluate the acute and sub -chronic ( 90 d; repeated dose ) toxicity of Withania somnifera (ashwagandha) extract in rats. Method s: The acute toxicity was evaluated as per OECD (Organisation for Economic Co -operation and Development) guidelines 423. P urified ashwagandha extract (PAE) was fed at 2000 mg/kg body weight (bw) to overnight fasted female rats. The animals were observed daily for clinical signs of abnormality/mortality. After 1 4 d , animals were sacrificed and gross pathologic al changes were recorded. Sub -chronic toxicity of PAE was studied by feeding the extract at 100, 500 and 1000 mg/kg bw daily to rats as per OECD guidelines 408 . After 9 0 d feeding , heamatological and biochemical parameters of treated rats were compared wit h control animals. Histopathology of all the major organs was also studied. Result s: In the acute toxicity study, no mortality or clinical signs of toxicity were observed in any of the animals at maximum recommended dose level of 2000 mg/kg b w; therefore the LD50 is >2000 mg/kg bw in rats. The repeated administration of PAE for 9 0 d in rats at the maximum dose level of 1000 mg/kg bw did not induce any observable toxic effects, when compared to its corresponding control animals. The hematology and biochemistr y profile of treated rats was similar to control animals and difference was non -significant (p>0.05). The histopathology of major organs of all the control and treated animals w as normal. In this study the NOAEL (No Observed Adverse Effect Level) was calcu lated as 1000 mg/kg bw daily for rats. Conclusio n: The present study clearly indicates that PAE does not have any toxic effects in animals at the dose evaluated as evidenced by acute and sub chronic toxicity studies in rats | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
|
| 700 |
_912222 _aBenny, Merina |
||
| 773 | 0 |
_dBhopal Innovare Academic Sciences Pvt Ltd _tInternational journal of pharmacy and pharmaceutical science _x2656-0097 |
|
| 856 |
_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/29493/16284 _yClick here |
||
| 942 |
_2ddc _cAR |
||