000			a
999			_c11282 _d11282
003			OSt
005			20200215084722.0
008			200215b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_912300 _aKottakki, Naveen Kumar
245			_aSYNTHESIS AND ANTIBACTERIAL ACTIVITY OF PIPERAZINE ANALOGUES CONTAINING [1, 3, 4]-OXADIAZOLE RING
250			_aVol.57(01), Jan
260			_aMumabi _bIndian Drug Manufacture's Association - IDMA _c2020
300			_a19-26p.
520			_aA new series of piperazine-1, 3, 4-oxadiazole deviatives were synthesized by the condensation of 1, 3, 4-thidaizole with substituted piperazine, in the presence of N, N-diisopropylethylamine. The structures were confirmed by IR, 1H NMR, 13C NMR and Mass spectroscopy. All the precursors were screened for anti-bacterial activity and the results indicate that phenyl substituted chloro (PO2) and hydroxy (PO6) functional derivatives possess better anti-bacterial activity towards to Gram-positive bacteria and gram-negative bacteria, Maximum zone of inhibition was observed in (PO2) against Bacillus subtillus (14.0 mm) and (PO6) against Pseudomonas aeruginosa (14.0 mm). Piperazine-1, 3, 4-oxadiazoles were synthesized by combining two active molecules into a new bioactive conjugate molecule. These new hybrid molecules have more potential biological activity than their parent molecules
650		0	_94639 _aPHARMACEUTICS
700			_912301 _aSoujanya Kumari, P. V. D.
773	0		_dMumbai Indian Drug Manufactures Association _tIndian drugs
856			_uhttps://www.indiandrugsonline.org/issuesarticle-details?id=MTAxMA== _yClick here
942			_2ddc _cAR