000			a
999			_c11485 _d11485
003			OSt
005			20200925094010.0
008			200923b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_912595 _aSharma, Dheeraj Kumar
245			_aRole of Testosterone in Swimming Exercise-induced Analgesia in Rats
250			_aVol.53(4), Oct-Dec
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2019
300			_a675-681p.
520			_aObjective: “Feel good effect” of exercise is well known. Activation of pain inhibitory mechanisms after exercise is also well documented. Swimming is considered as a beneficial exercise as well as health-promoting sport. The significance of testosterone in swimming exercise-induced analgesia is yet to be understood. Therefore, it is worthwhile to investigate the significance of testosterone in swimming exercise-induced analgesia. Materials and Methods: The basal tail flick latencies of all animals were recorded by using tail flick analgesiometer. In order to observe the effect of testosterone on swimming exercise-induced analgesia, testicles of animals of some groups were surgically removed. Then animals were subjected to swimming sessions of different patterns. After swimming, tail flick latencies were measured. Results: Swimming sessions resulted in increase in pain thresholds of all animals. Castration negatively affected the degree of analgesia achieved in rats. However, daily treatment of testosterone propionate (500μg/kg, s.c.) improved swim-induced analgesia in castrated rats. Moreover, daily administration of naloxone hydrochloride (1mg/kg, i.p.) fifteen min prior to swimming suppressed testosterone therapy resulted in an increase in swim-induced analgesia in castrated animals. Conclusion: We concluded that testosterone plays a significant role in swimming exercise-induced analgesia in male Wistar albino rats and this positive effect of testosterone on pain threshold might be mediated through its probable effect on the endogenous opioid system.
650		0	_94639 _aPHARMACEUTICS
700			_912596 _aSingh, Neeraj Kumar
773	0		_dBengluru Association of Pharmaceutical Teachers of India (APTI) _tIndian journal of pharmaceutical education and research _x0019-5464
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes_53_4_675.pdf _yClick here
942			_2ddc _cAR