000			a
999			_c11491 _d11491
003			OSt
005			20200924145719.0
008			200924b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_912607 _aSuryawanshi, Vijendra Kumar
245			_aCharacterization of Thermal Fraction of Clarified Butter and its Applicability to Improve Bioavailability of Rosuvastatin
250			_aVol.53(4), Oct-Dec
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2019
300			_a716-723p.
520			_aAim: The present investigation shows confirmatory evidence for the complex formation of Rosuvastatin with a fraction of Clarified Butter. Materials and Methods: Fractions of Clarified Butter prepared according to thermal behavior at different temperatures (30°C, 40°C, 50°C). Rosuvastatin biform complex with Clarified Butter in the ratio (1:1) and (1:2) w/w were prepared. Physicochemical properties of all fractions of Clarified Butter was determined as per Indian Pharmacopoeia. The fractions were subject to Fourier-transform Infraredspectroscopy (FTIR), Differential Scanning Calorimeters (DSC) and in-vitro release studies (Simulated gastric fluid, pH 1.2 for 2 h and simulated intestinal fluid, pH 6.8 for 6 h). Results: Based on these investigations; the optimized ratio (1:1) w/w were further characterized for DSC and FTIR studies. Where Rosuvastatin exhibited a strong carbonyl band at 1543.05 cm−1, all fractions showed the disappearance of strong carbonyl band at 1543.05 cm−1, spectra of biform complex shifted to higher frequency 1747.51 cm−1 (13.29 % increase), that confirmed carboxylic and hydroxyl group of both saturated and unsaturated fatty acid present in Clarified Butter. From in vitro release study the highest percent release i.e. 99.23±0.08% of Rosuvastatin was obtained from 1:1 biform complex. DSC thermogram revealed the formation of eutectic mixture by lowering the peak of pure Clarified Butter (67.4°C) to 58.10°C due to the formation of biform complex. Conclusion: Thus, Clarified Butter and its fraction illustrated enhanced bioavailability of Rosuvastatin.
650		0	_94639 _aPHARMACEUTICS
700			_912608 _aSakarkar, Suhas Narayan
773	0		_x0019-5464 _tIndian journal of pharmaceutical education and research _dBengluru Association of Pharmaceutical Teachers of India (APTI)
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes_53_4_716.pdf _yClick here
942			_2ddc _cAR