000			a
999			_c11492 _d11492
003			OSt
005			20200924151538.0
008			200924b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_912609 _aGunda, Raghavendra Kumar
245			_aFormulation Development and Evaluation of Gastro Retentive Bio Adhesive Drug Delivery System for Moxifloxacin. HCl
250			_aVol.53(4), Oct-Dec
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2019
300			_a724-732p.
520			_aObjective: The purpose of present research work is to develop gastro retentive formulation for Moxifloxacin using various drug release modifiers. Moxifloxacin, novel synthetic fluoro quinolone, antibacterial agent. Methods: SR granules were prepared by gastro retentive tablets of Moxifloxacin. HCl were prepared using variable amounts of HPMCK100M, Lannea coromandelica gum (LCG) by moist granulation technique. Totally 10 SR granule formulations were prepared and subjected to precompression analysis and drug release profiles. Based on the results screening of concentrations for polymers and are used for Tablet formulations. Six tablet formulations were designed and are evaluated for various pharmacopoeial tests. Drug release profiles of formulation trails subjected to kinetic modeling. a,b,r were determined. Results: The results reveals that retention time decreases with decreased viscosity of polymer. F16 prepared with LCG was found to have highest swelling property. High bioadhesive strength of the formulation is likely to increase its GI residence time. Lannea coromandelica gum powder needs to explored as a sustain release material at commercial scale.
650		0	_94639 _aPHARMACEUTICS
700			_912610 _aArumugam, Vijayalakshmi
773	0		_x0019-5464 _dBengluru Association of Pharmaceutical Teachers of India (APTI) _tIndian journal of pharmaceutical education and research
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes_53_4_724.pdf _yClick here
942			_2ddc _cAR