| 000 | a | ||
|---|---|---|---|
| 999 |
_c15568 _d15568 |
||
| 003 | OSt | ||
| 005 | 20211123152550.0 | ||
| 008 | 211123b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
||
| 100 |
_914773 _aWei, Tianhu |
||
| 245 | _a Anti-inflammatory and Anti-arthritic Activity of Rosmarinic acid Isolated from Rosmarinus officinalis in an Experimental Model of Arthritis | ||
| 250 | _aVol.55(2), Apr-Jun | ||
| 260 |
_aBanaglore _bAssociation of Pharmaceutical Teachers of India (APTI) _c2021 |
||
| 300 | _a507-516p. | ||
| 520 | _aBackground: Rosmarinus officinalis L. (family Lamiaceae is a perennial herb or small woody evergreen tree, commonly known as rosemary, which is native to the Mediterranean and Asia and reasonably hardy in cool climates. It has been used as a decoction in traditional Unani and Swedish medicine for the treatment of inflammatory diseases. Aim: To isolate rosmarinic acid (RA) from R. officinalis. leaf extract and to evaluate its protective effects against Freund’s adjuvant-induced arthritis in rats. Materials and Methods: Arthritis was induced via sub-plantar injection of 1mg heat-killed Mycobacterium tuberculosis (complete Freund’s adjuvant, CFA) into the left hind paw of rats. The experiment was designed and optimized based on published methods. Results: At 60 mg/kg, the RA fraction of the methanolic extract of R. officinalis L. exerted potentially effective anti-arthritic effects by controlling inflammation in an adjuvant-induced experimental model. Conclusion: Considering experimental findings relating to pharmacological and biochemical parameters, we conclude that oral administration of the RA fraction (30 and 60 mg/kg) from the methanolic extract of R. officinalis L. exerts anti-arthritic effects and controls inflammation in an adjuvant-induced arthritis rat model. RA is therefore a promising plant-derived anti-arthritic agent for the treatment of inflammatory disorders. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
|
| 700 |
_914774 _a Liu, Yuan |
||
| 773 | 0 |
_dBengluru Association of Pharmaceutical Teachers of India (APTI) _tIndian journal of pharmaceutical education and research _x0019-5464 |
|
| 856 |
_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-55-2-507.pdf _yClick here |
||
| 942 |
_2ddc _cAR |
||