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005			20211124100426.0
008			211124b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_98158 _aAbhishek Kumar
245			_aSynthesis, Antidiabetic Evaluation and Bioisosteric Modification of Quinoline Incorporated 2-pyrazoline Derivatives
250			_aVol.55(2), Apr-Jun
260			_aBanaglore _bAssociation of Pharmaceutical Teachers of India (APTI) _c2021
300			_a574-580p.
520			_aBackground: Diabetes mellitus is a pervasive illness worldwide with many progressively increasing complications day by day. The quinoline nucleus is important heterocyclic moiety with different biological activities. Due to their pivotal role in different biological processes they are well explored as therapeutic agents and some of them have exhibited antihyperglycemic activity. Different substituted pyrazoles have been accounted for their in vivo antidiabetic activity, but we concentrated to substituted pyrazoline derivatives in the quest for novel basic classes of medications inhibiting the action of the ATP-K+ beta cell pancreatic membrane channel, prompting the release of insulin. Materials and Methods: In the present study, 1-(4-(7-Chloroquinolin-4-yl oxy) phenyl ethanone and 1-(4-(7-Chloroquinolin-4-yl amino) phenyl ethanone was synthesized by nucleophilic substitution of 4-Chloro of 4,7-dichloroquinoline with substituted 4-hydroxy acetophenone and 4-amino acetophenone in DMF and KOH respectively. The amino linked chalcones and oxo linked chalcones was synthesized by Clasein Schmidt condensation with different substituted aromatic aldehydes. Finally substituted pyrazolines (ACP1-ACP10) was synthesized upon cyclisation of oxo linked and amino linked chalcones with hydrazine hydrate. The structures of the final synthesized compounds were characterized by IR, 1H NMR and mass spectra. Results: The final synthesized compounds were evaluated for their in vitro antidiabetic activity by alpha glucosidase inhibition assay. Most of the compounds showed good antidiabetic activity compared to the standard drug acarbose. Conclusion: In-vitro results revealed that a large number of synthesized compounds having good antidiabetic activity. So these compounds are found to be interesting lead molecules for further synthesis as antidiabetic agents.
650		0	_94639 _aPHARMACEUTICS
700			_914787 _aPankaj Kumar
773	0		_tIndian journal of pharmaceutical education and research _x0019-5464 _dBengluru Association of Pharmaceutical Teachers of India (APTI)
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-55-2-574.pdf _yClick here
942			_2ddc _cAR