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999 _c15865
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040 _aAIKTC-KRRC
_cAIKTC-KRRC
100 _915286
_aSukender Kumar
245 _aDemystifying therapeutic potential of medicinal plants against chikungunya virus
250 _aVol.53(5), Sep-Oct
260 _aMumbai
_bWolter Kluwer
_c2021
300 _a403-411p.
520 _aViral infections are posing a great threat to humanity for the last few years. Among these, Chikungunya which is a mosquito‑borne viral infection has produced enormous epidemics around the world after been rebounded. Although this infection shows a low mortality rate, patients suffer from fever, arthralgia, and maculopapular rashes, which reduce the quality of life for several weeks to years. The currently available treatments only provide symptomatic relief based on analgesics, antipyretics, and anti‑inflammatory drugs which are nonspecific without satisfactory results. Medicinal plants are a widely accepted source of new molecules for the treatment of infectious diseases including viral infections. The scientific reports, primarily focusing on the anti‑chikungunya activity of plant extracts, natural origin pure compounds, and their synthetic analog published from 2011 to 2021, were selected from PubMed, Google Scholar, and Scopus by using related keywords like anti‑chikungunya plants, natural antivirals for Chikungunya. The present review decodes scientific reports on medicinal plants against chikungunya virus (CHIKV) infection and demystifies the potential phytoconstituents which reveals that the screening of flavonoids containing plants and phytochemicals showing efficacy against other arbovirus infections, may prove as a potential lead for drug development against CHIKV. The present article also outlines pathogenesis, clinical aspects, molecular virology, and diagnostic approaches of CHIKV infection.
650 0 _94774
_aPHARMACOLOGY
700 _915287
_a Garg, Chanchal
773 0 _x0253-7613
_dAndheri - Mumbai Wolters Kluwer India Private Limited
_tIndian Journal of Pharmacology
856 _uhttps://www.ijp-online.com/temp/IndianJPharmacol535403-2206457_060744.pdf
_yClick here
942 _2ddc
_cAR