000			a
999			_c15866 _d15866
003			OSt
005			20220101093341.0
008			220101b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915288 _a Bhatt, Parloop
245			_aComparative effectiveness of metoprolol, ivabradine, and its combination in the management of inappropriate sinus tachycardia in coronary artery bypass graft patients
250			_aVol.53(4), July-Aug
260			_aMumbai _bWolter Kluwer _c2021
300			_a264-269p.
520			_aBACKGROUND: Inappropriate sinus tachycardia (IST) is an arrhythmic complication observed after coronary artery bypass graft (CABG) surgery which left untreated, commonly increases chances of postoperative stroke. The primary study objective was comparing effectiveness of beta blocker‑metoprolol; a specific If blocker‑ivabradine and its combination in patients who develop IST as a complication following CABG. MATERIALS AND METHODS:An open‑labeled, investigator initiated, clinical study was conducted on 150 patients who developed IST (heart rate [HR] >100 beats/min) following elective CABG surgery. The patients were randomized into three treatment groups. Group I – received ivabradine (5 mg), Group II – metoprolol (25 mg), and Group III – ivabradine (5 mg) and metoprolol (25 mg). Treatment was given orally, twice a day for 7 days in all the three groups postoperatively. Primary endpoints were comparative effectiveness in HR and blood pressure reduction following treatment. RESULTS: IST was diagnosed by an electrocardiogram (12‑lead) considering morphological features of P‑wave and with 32% increase from baseline HR in all the three groups. Compared to IST arrthymic rate, HR was reduced in all groups following respective treatment (P = 0.05). Reduction in HR was significant (P < 0.05) in combination group followed by ivabradine which was significantly greater than metoprolol treated group. None of the treatments clinically changed the systolic, diastolic and mean blood pressure till discharge. No surgery/treatment‑related complications were observed in any groups. CONCLUSION: Ivabradine stands as a pharmacological option for controlling HR and rhythm without associated side effects in postoperative CABG patients with IST
650		0	_94774 _aPHARMACOLOGY
700			_915289 _a Bhavsar, Niren
773	0		_dAndheri - Mumbai Wolters Kluwer India Private Limited _tIndian Journal of Pharmacology _x0253-7613
856			_uhttps://ijp-online.com/temp/IndianJPharmacol534264-1426397_035743.pdf _yClick here
942			_2ddc _cAR