| 000 | a | ||
|---|---|---|---|
| 999 |
_c15995 _d15995 |
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| 003 | OSt | ||
| 005 | 20220119115026.0 | ||
| 008 | 220119b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_915491 _aAlshargabi, Arwa |
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| 245 | _aIn vitro assessment of physicochemical parameters of five generics amlodipine besylate tablets marketed in yemen | ||
| 250 | _aVol.13 (11) | ||
| 260 |
_aBhopal _bInnovare Academic Sciences Pvt Ltd _c2021 |
||
| 300 | _a15-19p. | ||
| 520 | _aObjective: The present paper aims to evaluate the quality of five different brands (local and imported) of oral film-coated tablets of generic Amlodipine besylate 5 mg marketed in Sana`a-Yemen, through physiochemical parameters. Methods: Different physicochemical parameters, including the uniformity of tablet weight, hardness, thickness, disintegration time, and an assay of active ingredients, were conducted to validate the quality of generics Amlodipine Besylate 5 mg according to USP specification. Results: From the obtained results, it was observed that all the brands of Amlodipine Besylate 5 mg have passed the tests and met the specifications of USP. Results of weight variation, hardness, thickness, and disintegration time were ranged from-3.8 % to+5.13 % to-1.25 % to+3.25 %, 5.06±0.31 to 13.21±1.5, 2.682±0.04 to 3.676±0.01 and 25 s to 2 min: 30 s, respectively. The dissolution test and the assay results of all the brands are also ranged within the acceptable label claim 93.7±2.24 to 98.4±0.85 and 93.22±0.38 to 100.15±0.33, respectively. However, there is no relation was found between the disintegration time and the dissolution test. Conclusion: According to the finding, all the selected Amlodipine Besylate 5 mg brands are met pharmacopeia standards and USP specifications. Therefore, the local and imported Amlodipine Besylate 5 mg can be used safely to get the desired therapeutic efficiency. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 653 | _aAmlodipine | ||
| 653 | _aHypertension | ||
| 653 | _aUnited stat of pharmacopeia | ||
| 773 | 0 |
_x2656-0097 _dBhopal Innovare Academic Sciences Pvt Ltd _tInternational journal of pharmacy and pharmaceutical science |
|
| 856 |
_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/42898/25574 _yFull Article |
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| 942 |
_2ddc _cAR |
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