000			a
999			_c17240 _d17240
003			OSt
005			20220730150114.0
008			220730b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_917430 _aBhattacharjee, Ananya
245			_aProtective effect of ellagic acid against lead-induced reproductive toxicity in male rats
250			_aVol.16(2), Apr-Jun
260			_aMandsaur _bBRNSS Publication Hub. _c2022
300			_a198-202p.
520			_aIntroduction: Infertility affects many couples especially in developing countries and is a reproductive health problem worldwide. The widespread use of heavy metals like lead has led to manifold rise in the occurrence of free lead in biological systems and the inert environment. The detrimental effect on male reproductive system is one of the major evidence of occupational and environmental lead exposure. It has been documented that the presence of higher amounts of lead in the blood of exposed workers compared to control workers is associated with reduced volume of ejaculation, decreased total sperm number and motility, and reduction in semen density, as well as increased percentage of pathological spermatozoa. Materials and Methods: The lead-induced reproductive toxicity study was carried out in healthy adult male Wister albino rats. Rat doses of ELLAGIC acid (EA) were selected as 50 mg/kg and 25 mg/kg through oral route. After acclimatization, animals were divided into four random groups of eight animals in each; received normal saline, lead acetate, and EA high and low doses along with lead acetate, respectively, for 70 days. Serum was separated by centrifugation for the estimation of testosterone level by ELISA. Thereafter, the animals were sacrificed; testis was weighed and used for the epididymal sperm count, motility, and viability and then for preparation of homogenate to estimate antioxidants such as super oxide dismutase, catalase, and thiobarbituric acid reactive substances. Remaining testis was embedded in formaline in saline solution (10%) for histological examination. Results, Discussion, and Conclusion: Observed results suggested dose dependent beneficial effects for EA against lead acetate induced male reproductive toxicity and it was concluded that EA exhibited dose-dependent protection against lead-induced male reproductive toxicity. Key words: Ellagic acid, heavy metal toxicity, lead acetate, male reproductive toxicity
650		0	_94774 _aPHARMACOLOGY
700			_916053 _aKulkarni, Venkatrao H.
700			_912164 _aHabbu, Prasanna V.
773	0		_dMandsaur B.R. Nahata Smriti Sansthan _tInternational journal of green pharmacy _x0973-8258
856			_uhttps://www.greenpharmacy.info/index.php/ijgp/article/view/3254
942			_2ddc _cAR